<?xml version="1.0" encoding="UTF-8"?>

<wo-patent-document lang="it" status="Registered" country="SM">
  <wo-bibliographic-data status="Brevetto concesso">
    <application-reference>
      <document-id>
        <country>SM</country>
        <doc-number>T/2026/000345</doc-number>
        <date>20170414</date>
      </document-id>
    </application-reference>
    <priority-claims>
      <priority-claim sequence="0001" kind="national">
        <country>US</country>
        <doc-number>201662410842 P</doc-number>
        <date>20161020</date>
      </priority-claim>
      <priority-claim sequence="0002" kind="national">
        <country>US</country>
        <doc-number>201662394745 P</doc-number>
        <date>20160914</date>
      </priority-claim>
      <priority-claim sequence="0003" kind="national">
        <country>US</country>
        <doc-number>201762472568 P</doc-number>
        <date>20170316</date>
      </priority-claim>
      <priority-claim sequence="0004" kind="national">
        <country>US</country>
        <doc-number>201662323608 P</doc-number>
        <date>20160415</date>
      </priority-claim>
      <priority-claim sequence="0005" kind="national">
        <country>US</country>
        <doc-number>201762475162 P</doc-number>
        <date>20170322</date>
      </priority-claim>
    </priority-claims>
    <parties>
      <applicants>
        <applicant sequence="0001" app-type="applicant" designation="all">
          <addressbook lang="it">
            <name>ALPINE IMMUNE SCIENCES, INC.</name>
            <address>
              <address-1>188 East Blaine StreetSuite 200, Seattle, WA 98102, US</address-1>
              <country>US</country>
            </address>
          </addressbook>
          <nationality>
            <country/>
          </nationality>
          <residence>
            <country>US</country>
          </residence>
        </applicant>
      </applicants>
      <inventors>
        <inventor sequence="0001">
          <addressbook lang="it">
            <name>SWANSON, Ryan</name>
            <address>
              <address-1>201 Elliott Ave. WestSuite 230, SeattleWA 98119, US</address-1>
              <country>US</country>
            </address>
          </addressbook>
        </inventor>
        <inventor sequence="0002">
          <addressbook lang="it">
            <name>KORNACKER, Michael</name>
            <address>
              <address-1>201 Elliott Ave. WestSuite 230, SeattleWA 98119, US</address-1>
              <country>US</country>
            </address>
          </addressbook>
        </inventor>
      </inventors>
      <agents>
        <agent sequence="0001" rep-type="agent">
          <addressbook lang="it">
            <name>DE BENEDETTI, Jacopo</name>
            <address>
              <address-1>Via L. Cibrario, 25, 47893 Borgo Maggiore RSM , SM</address-1>
              <country>SM</country>
            </address>
          </addressbook>
        </agent>
      </agents>
    </parties>
    <invention-title lang="it">PROTEINE IMMUNOMODULATORIE VARIANTI DI LIGANDO DI ICOS E RELATIVI USI</invention-title>
    <invention-title lang="en">ICOS LIGAND VARIANT IMMUNOMODULATORY PROTEINS AND USES THEREOF</invention-title>
    <wo-term-of-grant>
      <date>20260813</date>
      <doc-number>2026000345</doc-number>
    </wo-term-of-grant>
    <pct-or-regional-filing-data>
      <document-id>
        <country>17</country>
        <doc-number>PCT/17733114.7</doc-number>
        <date>20170414</date>
      </document-id>
    </pct-or-regional-filing-data>
    <pct-or-regional-publishing-data>
      <document-id>
        <country>EP</country>
        <doc-number>WO/3442999</doc-number>
        <date>20260701</date>
      </document-id>
    </pct-or-regional-publishing-data>
    <wo-national-office-event national-office-event-type="Filed" doc-number="SM/T/2026/000345" event-name="Filing">
      <wo-national-office-event-date>
        <date>20170414</date>
      </wo-national-office-event-date>
    </wo-national-office-event>
    <wo-national-office-event national-office-event-type="Registered" event-name="Brevetto EPO concesso">
      <wo-national-office-event-date>
        <date>20260813</date>
      </wo-national-office-event-date>
    </wo-national-office-event>
    <wo-national-office-filing-data appl-type="Brevetti EPO No.3442999    2026.07.01" file-type="T">
      <kind-of-protection>Brevetti EPO</kind-of-protection>
    </wo-national-office-filing-data>
  </wo-bibliographic-data>
</wo-patent-document>
