<?xml version="1.0" encoding="UTF-8"?>

<wo-patent-document lang="it" status="Registered" country="SM">
  <wo-bibliographic-data status="Brevetto concesso">
    <application-reference>
      <document-id>
        <country>SM</country>
        <doc-number>T/2026/000338</doc-number>
        <date>20140501</date>
      </document-id>
    </application-reference>
    <priority-claims>
      <priority-claim sequence="0001" kind="national">
        <country>US</country>
        <doc-number>201361818442 P</doc-number>
        <date>20130501</date>
      </priority-claim>
      <priority-claim sequence="0002" kind="national">
        <country>US</country>
        <doc-number>201461976991 P</doc-number>
        <date>20140408</date>
      </priority-claim>
      <priority-claim sequence="0003" kind="national">
        <country>US</country>
        <doc-number>201361871673 P</doc-number>
        <date>20130829</date>
      </priority-claim>
      <priority-claim sequence="0004" kind="national">
        <country>US</country>
        <doc-number>201461986867 P</doc-number>
        <date>20140430</date>
      </priority-claim>
      <priority-claim sequence="0005" kind="national">
        <country>US</country>
        <doc-number>201361843887 P</doc-number>
        <date>20130708</date>
      </priority-claim>
      <priority-claim sequence="0006" kind="national">
        <country>US</country>
        <doc-number>201361880790 P</doc-number>
        <date>20130920</date>
      </priority-claim>
      <priority-claim sequence="0007" kind="national">
        <country>US</country>
        <doc-number>201361823826 P</doc-number>
        <date>20130515</date>
      </priority-claim>
    </priority-claims>
    <parties>
      <applicants>
        <applicant sequence="0001" app-type="applicant" designation="all">
          <addressbook lang="it">
            <name>IONIS PHARMACEUTICALS, INC.</name>
            <address>
              <address-1>2855 Gazelle Court, Carlsbad, CA 92010, US</address-1>
              <country>US</country>
            </address>
          </addressbook>
          <nationality>
            <country/>
          </nationality>
          <residence>
            <country>US</country>
          </residence>
        </applicant>
      </applicants>
      <inventors>
        <inventor sequence="0001">
          <addressbook lang="it">
            <name>SETH, Punit P.</name>
            <address>
              <address-1>, Carlsbad, 92010, US</address-1>
              <country>US</country>
            </address>
          </addressbook>
        </inventor>
        <inventor sequence="0002">
          <addressbook lang="it">
            <name>PRAKASH, Thazha P.</name>
            <address>
              <address-1>, Carlsbad, 92010, US</address-1>
              <country>US</country>
            </address>
          </addressbook>
        </inventor>
        <inventor sequence="0003">
          <addressbook lang="it">
            <name>SWAYZE, Eric E.</name>
            <address>
              <address-1>, Carlsbad, 92010, US</address-1>
              <country>US</country>
            </address>
          </addressbook>
        </inventor>
      </inventors>
      <agents>
        <agent sequence="0001" rep-type="agent">
          <addressbook lang="it">
            <name>PERRONACE, Andrea</name>
            <address>
              <address-1>Via Tre Settembre, 154, 47891 Dogana RSM, SM</address-1>
              <country>SM</country>
            </address>
          </addressbook>
        </agent>
      </agents>
    </parties>
    <invention-title lang="it">COMPOSIZIONI E METODI PER MODULARE L'ESPRESSIONE DI HBV E TTR</invention-title>
    <invention-title lang="en">COMPOSITIONS AND METHODS FOR MODULATING HBV AND TTR EXPRESSION</invention-title>
    <wo-term-of-grant>
      <date>20260811</date>
      <doc-number>2026000338</doc-number>
    </wo-term-of-grant>
    <pct-or-regional-filing-data>
      <document-id>
        <country>25</country>
        <doc-number>PCT/25155370.7</doc-number>
        <date>20140501</date>
      </document-id>
    </pct-or-regional-filing-data>
    <pct-or-regional-publishing-data>
      <document-id>
        <country>EP</country>
        <doc-number>WO/4529927</doc-number>
        <date>20260708</date>
      </document-id>
    </pct-or-regional-publishing-data>
    <wo-national-office-event national-office-event-type="Filed" doc-number="SM/T/2026/000338" event-name="Filing">
      <wo-national-office-event-date>
        <date>20140501</date>
      </wo-national-office-event-date>
    </wo-national-office-event>
    <wo-national-office-event national-office-event-type="Registered" event-name="Brevetto EPO concesso">
      <wo-national-office-event-date>
        <date>20260811</date>
      </wo-national-office-event-date>
    </wo-national-office-event>
    <wo-national-office-filing-data appl-type="Brevetti EPO No.4529927    2026.07.08" file-type="T">
      <kind-of-protection>Brevetti EPO</kind-of-protection>
    </wo-national-office-filing-data>
  </wo-bibliographic-data>
</wo-patent-document>
